Fragile X Syndrome

A genetic condition caused by a mutation in the FMR1 gene on the X chromosome, making it the most common inherited cause of intellectual disability and the most common known single-gene cause of autism spectrum disorder. Fragile X affects males more severely than females, with symptoms ranging from learning disabilities and attention difficulties to moderate or severe intellectual disability. Common characteristics include anxiety, sensory sensitivities, speech and language delays, and difficulties with executive function. In digital accessibility contexts, people with Fragile X may benefit from simplified interfaces, reduced visual clutter, consistent navigation patterns, predictable interactions, and content presented in plain language with visual supports.