Leber Hereditary Optic Neuropathy

A maternally inherited genetic condition that causes sudden or rapid loss of central vision, typically affecting young adults between the ages of 15 and 35. LHON results from mutations in mitochondrial DNA that damage the optic nerve, leading to significant bilateral central vision loss while peripheral vision is usually preserved. Most people with LHON are classified as having low vision rather than total blindness, and some experience partial recovery over time. The condition predominantly affects males and is one of the more common inherited optic neuropathies, with an estimated prevalence of about 1 in 30,000 to 50,000 people.